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A Review of Treatment Approaches for Spinal Cord Injury Improvement
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Mohammad Amin Jafarimanesh   , Jafar Ai * , Shahrokh Shojae , Hossein Ali Khonakdar , Goldis Darb Emamieh , Sadegh Shirian |
| Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran , jafar_ay2000@yahoo.com |
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Abstract: (154 Views) |
Introduction: Spinal cord injury (SCI) is a serious condition leading to complete or partial sensory and motor dysfunction. Currently, drug therapy, surgical decompression, and postoperative rehabilitation are the main potential treatments for SCI. Due to the complexity of the pathological microenvironment of SCI, there is no fully effective treatment approach. Investigations on SCI treatment are increasing to find drugs or methods that can help patients with SCI. In experimental studies, stem cell-based therapy and their derived exosomes, as well as certain drugs, hold significant promise for SCI treatment. This review study focuses on the latest advancements in SCI treatment. Data were collected from the PubMed, Scopus, Web of Science, and ScienceDirect databases. Conclusion: Compared to stem cells, exosomes offer advantages, such as neuroprotection, low immunogenicity, ease of storage and transport, axonal regeneration, small size that avoids capture by lung and liver tissues, and the ability to cross the blood-spinal cord barrier. Biomaterials provide a supportive microenvironment, while exosomes and stem cells continuously release growth factors to help in various pathological conditions, such as SCI.
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| Keywords: Neurologic Manifestations, Neuroprotective Agents, Exosomes, Stem Cells |
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Full-Text [PDF 456 kb]
(19 Downloads)
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Type of Study: Review --- Open Access, CC-BY-NC |
Subject:
Basic research in Neuroscience
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